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Acknowledgements The authors acknowledge the support of grants from Inserm, CNRS, Universit Paris Cit, Agence Nationale de la Recherche (ANR), Socit Francophone du Diabte (SFD), Fondation pour la Recherche Mdicale (FRM), the Dutch Organization for Scientific Research (ZonMW) and DiabetesFonds

The total effect ( c ) of X on Y comprises the direct effect ( c ) after accounting for the mediator and the indirect effect ( aXb ) through the M

vitamin C may protect immune and nearby cells from damage by these substances