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Underlying kidney function : Some GLP-1 receptor agonists have shown benefits for renal outcomes in clinical trials, though this varies by specific medication

In a clinical trial of more than 3,000 adults with obesity, participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight -- about 25 pounds on average -- over more than 16 months

This article breaks down that paradox, explains why discomfort is such a powerful biological signal, and shows how intensity shapes everything from lactate metabolism to brain chemistry to long-term resilience