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The rationale for studying semaglutide in the phase 3 evoke/evoke+ program without prior phase 1/2 trials of semaglutide in early AD was based on several factors

Estrogens play a major role in enhancing the GH response to GHSs at puberty, which GHRH hypoactivity, somatostatinergic hyperactivity and impaired activity of the putative GHS-like ligand and receptors probably explain the reduced GH-releasing effect of GHSs in aging

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doi: 10.1007/s00018-010-0396-5 28 MeierJJ