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The prolonged duration of withdrawal symptoms and the enduring distress experienced by individuals undergoing drug withdrawal [3,4,70] contribute to the complexity of relapse causation [3,7173]

"The whole point of this kind of approach is that it can move quickly, and that's exactly when it's most valuable," says Guntuku

This will enhance the permeability of the intestinal barrier leading to so called leaky gut. Subsequently, hyperglycemia may facilitate the dispersal of an enteric infection into a systemic infection (Figure 1) (76)