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10.1097/imna-d-23-00029 137 LiuD.ShiR.LiL.YangL.YangY.WuX.et al (2024b)

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Major metabolic disorders in MDD include abnormalities in lipid metabolism characterized by diminished reverse cholesterol transport (RCT) and heightened atherogenicity, disruptions in protein metabolism resulting in reduced total serum protein and decreased plasma tryptophan availability to the brain, and nutritional immunity with immune-linked alterations in trace elements such as iron and zinc [5, 6]