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BPC-157 doesn't just increase collagen production it improves collagen organization and crosslinking, leading to stronger, more resilient tissue

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Regulatory Note: AOD 9604 has been designated Generally Recognized As Safe (GRAS) for certain food-related applications by an expert panel, but is not FDA-approved for medical or dietary use

Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly