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doi: 10.3390/biomedicines10081956 32 CiarloL.ManganelliV.MatarreseP.GarofaloT.TinariA.GambardellaL.et al

The combination itself has not been validated in controlled human trials

Further studies are needed to confirm the effects of smoking cessation on endothelial function using an appropriate study design, several smoking cessation methods, short- to long-term follow-up periods, different grades of smoking status, and diverse subjects including subjects with advanced atherosclerosis and healthy subjects in large clinical trials