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Tirzepatide activates both pathways, which is one reason Mounjaro can affect appetite and body weight

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In patients who were normoglycemic at baseline| || || ||||||||||| |||||||| ||| ||| || ||||||| |||||||| were prediabetic by the end of trial, and in patients with prediabetes at baseline ||| || ||| ||||||||||| ||||| ||| ||| || ||| ||||||| ||||| |||||| ||||||||||||| || |||| |||, and || |||||||| || ||| ||||||||||| ||||| ||| || || |||||||| || ||| ||||||| ||||| |||| || || ||||||| |||||||| || ||| || |||||