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The standard titration increases the dose every four weeks, with 5 mg serving as the minimum maintenance dose and 15 mg the maximum used in obesity trials

Whether CagriSema ultimately occupies a meaningful commercial position in the obesity market will depend substantially on how the FDA evaluates the REDEFINE evidence package and how payers and prescribers weigh a well-evidenced but second-ranked option against the existing approved standard.

The body doesn't want you to lose weight

While the list of pathophysiologic defects continues to grow, the ominous octet provides a representation of 8 key defects found in T2DM ( Figure 1 )