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Accumulating evidence indicates that central sensitization is a critical mechanism of CM, which manifests as neuronal plastic changes in the trigeminal nucleus caudalis (TNC) [7,8,9]

Keeping a symptom diary can be useful as a basis for discussions about symptoms, impairments, and the associated feelings and conceptions

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Novo has also not developed nor deployed written procedures for the surveillance, receipt and reporting to FDA of post marketing adverse drug experiences, the report stated