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While this medication offers significant metabolic and cardiovascular benefits, clinical trials have documented modest increases in resting heart rate among some patients

In addition, early reports of suicidality associated with these agents resulted in regulatory investigations concluding that cause and effect cannot be established but should continue to be a variable for further evaluation.Reference McIntyre, Mansur, Rosenblat and Kwan 24 , Reference McIntyre, Mansur and Rosenblat 51 Reference Wang, Volkow, Berger, Davis, Kaelber and Xu 53 In conclusion, our overarching aim is to encourage comprehensive assessments of whether semaglutide (and/or other incretin receptor agonists) is capable of exerting nephroprotective effects in persons exposed to lithium

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Increases Metabolism