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King Trust to B.P.C., and by the German Research Foundation (DFG

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One of the plausible explanations is that cancer cells with higher levels of iron can support fast proliferation ( SystemX c /glutathione axis SystemX c is a heterodimer cell surface amino acid transporter extensively located in the cell membrane, which is a vital component of the cellular antioxidant system ( c is composed of the transport subunit SLC7A11 and regulatory subunit SLC3A2 structurally, which are coupled by a disulfide bond ( c was capable of transferring cystine into cells and simultaneously exchanging glutamate at a ratio of 1:1 in an ATP-independent manner ( via inhibiting SLC7A11 by traditional drugs (e.g., sorafenib and sulfasalazine (SAS)) or novel compounds (e.g., erastin), thus inducing ferroptosis (Zhang et al., 2018), tumor protein 53 (TP53) ( c could induce ferroptosis in vitro (Yang et al., 2014)