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Contrave should not be used by individuals who are currently taking opioids or have a history of opioid dependence, as it can trigger withdrawal symptoms, which can be severe and may require hospitalization. Additionally, Contrave may interact with monoamine oxidase inhibitors (MAOIs), opioids, other weight loss drugs, drugs that lower the seizure threshold, and certain other medicines

Toxicology Reports , 7, 628640

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The study, published online Feb