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Glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus

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As the impact of diabetes pathogenesis has been intensively studied, there is growing evidence that people with impaired glucose tolerance and diabetes have an increased risk of developing cognitive dysfunction compared to healthy individuals, and a 50% increased risk of dementia in type 2 diabetes (T2DM) (2)

However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use