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Interestingly, systemic administration of an Y2R antagonist was shown to reverse increases in anxiety-like behavior after alcohol withdrawal, again implying that NPY signaling may regulate negative reinforcement (Cippitelli et al., 2011)

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Additional data presented from clinical case observations in patients with ACTH-secreting NETs suggest that upregulation of SSTR2 via GR modulation may re-sensitize tumors to endogenous somatostatin and/or somatostatin analogs