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It has been suggested that the effects of glutamine are mixed, and studies fail to demonstrate positive benefits on buffering capacity, time to exhaustion, protein balance, and other ergogenic effects regarding muscle recovery from exercise [135]

Clin Pharmacokinet 2012;51:553-72

Another sea creature, the Caribbean sea squirt, has provided us with the anti-cancer drug trabectedin

The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]