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Mol Ther 15:8693 Astrup A, Rssner S, Van Gaal L, Rissanen A, Niskanen L, Al Hakim M, Madsen J, Rasmussen MF, Lean ME, NN8022-1807 Study Group (2009) Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study

Most of the weight loss tends to come later, as the dose increases over the following months towards the 25 mg maintenance dose

For example, in the ADJUNCT ONE trial, the rate of nausea with the highest dose of liraglutide (1.8mg) was 49.6% compared to 12.1% in the placebo

Mechanisms of liver injury induced by smoking The detrimental effects of cigarette smoking on the liver are mediated through a complex interplay of toxic, immunologic, and oncogenic mechanisms