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Concurrently, the imbalance characterized by reduced beneficial bacteria such as Bifidobacterium and Lactobacillus , and proliferation of opportunistic pathogenic bacteria such as Enterobacteriaceae and Streptococcus significantly disrupts gut immune homeostasis, promoting chronic low-grade inflammation (Liu Y

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However, after GLP-1RAs treatment, the joint structural damage was significantly alleviated and osteophyte formation was reduced (Fig

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