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I had tried lifestyle changes

doi: 10.1097/XCE.0000000000000195

Part 2: The Cellular Fuel NAD+ If Glutathione is the sanitation crew, NAD+ (Nicotinamide Adenine Dinucleotide) is the power plant

Once in the nucleus, it binds to specific transcription factors and DNA elements particularly antioxidant response elements (ARE) that are regulated by the stress-responsive factor NRF2. Through this mechanism, MOTS-c can turn on a suite of stress-defense and metabolic genes that help cells adapt to high-fat stress or insulin resistance