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389 On the other hand, several studies with vasodilating -blockers such as nebivolol or carvedilol suggest favorable effects in terms of arterial elasticity, likely due to an increase in the bioavailability of NO

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Although PYC has been shown to reduce CRP levels, existing trials are limited by small sample sizes (e.g., five studies totaling approximately 324 participants in a CRP meta-analysis), high heterogeneity (I 2 99%), and variability in dosing regimens, treatment duration, and study populations ( Similarly, although PYCs anticancer effects have been demonstrated in multiple cell lines and preclinical models, translational data remain limited

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