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The resin was washed with a small amount of TFA and the filtrates were combined

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PGC-1, as a key regulator of mitochondrial biogenesis and transcriptional regulator, is involved in the regulation of BACE1 transcription

Corroborating this, it was found that food withdrawal is followed by SIRT1 binding and repression of genes controlled by the fat regulator PPAR- (peroxisome proliferator-activated receptor-), including genes mediating fat storage