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Further, 2/3 of patients relapse within the first year in abstinence-based treatment models 3

Further, our findings may not be generalisable to youth with severe hyperglycaemia or those on chronic treatment and, due to limitations in sample size, we were only able to explore potential mediators of metformin response

| Atributo | Retatrutida | Tirzepatida | Semaglutida | |---|---|---|---| | Receptores | GLP-1 + GIP + GCG | GLP-1 + GIP | GLP-1 | | Vida media estimada | ~6 das | ~5 das | ~7 das | | Va estudiada | Subcutnea semanal | Subcutnea semanal | Subcutnea / oral | | Reduccin ponderal fase 2 | Hasta 24.2% | Hasta 22.5% | Hasta 15-17% | | Componente termognico | S (GCG-R) | No | No | Historia y desarrollo Retatrutida (cdigo LY3437943) fue desarrollada por Eli Lilly and Company como evolucin del programa incretnico que dio origen a dulaglutida (mono-GLP-1) y tirzepatida (dual GLP-1/GIP, comercializada como Zepbound)