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Friedman notes that evidence from small randomized controlled trials and meta-analyses demonstrates meaningful reductions in Psoriasis Area and Severity Index (PASI) scores and corresponding improvements in quality-of-life measures with GLP-1 receptor agonists such as liraglutide and exenatide, including in patients without diabetes

Astrocytopathies with aberrant pathological astrocytes Aberrant astrocytes that may act as instigators and propagators of neuropathology have been described in several diseases

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14.1% of patients taking non-GLP-1 drug said they had suicidal thoughts after initiating the medication, twice the rate in the semaglutide group