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As this enzyme catalyzes a reversible reaction between isocitrate and -ketoglutarate, the inverse reaction, so called the reductive carboxylation, could occur to maintain TCA cycle intermediates under mitochondria defects

Together, these findings highlight that both pharmacological antidepressants and bioactive dietary compounds like flavonoids can shift KP metabolism toward neuroprotective pathways, offering potential avenues to alleviate inflammation-driven depressive pathology

Sanaei NezhadFAntonAParkesLMDeakinBWilliamsSR

In addition, you will improve sports performance, feel a satiating sensation and control your appetite more easily