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428 Spermidine Spermidine, a naturally occurring polyamine, is widely distributed in plant and animal tissues (e.g., cheese, legumes, mushrooms) and human cells, and its levels are maintained through dietary intake or endogenous synthesis

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comorbidities (essential hypertension, heart failure, ischemic heart disease, chronic kidney disease [CKD], cerebrovascular disease, overweight/obesity, dyslipidemia)

Singh said that studies from Mass Eye and Ear suggest semaglutide users may experience an increased risk of NAION, with one analysis reporting a 4.3-fold higher risk compared with comparators