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Similar to the PR8 (Fig 2A-IAV), we found CA04 infected DC significantly increased glycolysis, resulting in a mean difference of 17.60 95% CI [6.017, 29.18] while the increase by X31 was not significant (S4A Fig)

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Analysts at the time were bullish about these findings, with BMO Capital Markets noting that orforglipron achieved injectable like efficacy. Study participants also lost 7.9% body weight after orforglipron treatment, as compared with 1.6% in placebo

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