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These approvals reflect the expanding therapeutic role of GLP-1R agonists beyond glycemic control into broader cardiometabolic and respiratory domains Table 2

However, very long-term data spanning years to decades does not yet exist

On the one hand, disruption of these neurotransmitter metabolisms can result in the loss of innervation of monoamine neurons in the brain and induces depressive behaviors such as mood disorders (45, 49, 50)

b , i , l , o , Venn-diagram with differentially regulated proteins (DRPs) over vehicle in pancreas ( b ), eWAT ( i ), liver ( l ) and skeletal muscle ( o )