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The prevailing theory suggests that migraine is a neurovascular disorder initiated within the central nervous system (CNS), characterized by an increased sensitivity of the trigeminovascular system (TVS) leading to pain

Research suggests supplementing with zinc may help improve sleep quality, while magnesium helps activate your parasympathetic nervous system, which helps the brain and body relax before you fall asleep ( Magnesium appears to help regulate melatonin, a hormone that regulates your sleep-wake cycles, and bind to gamma-aminobutyric acid (GABA) receptors, which plays a role in slowing down nerve activity ( An 8-week study in 43 people with insomnia found that taking the combination of zinc, magnesium, and melatonin before bedtime improved sleep quality and reduced the time to sleep, compared with placebo treatment ( May support immunity Zinc, magnesium, and vitamin B6 have properties that may help support immunity

This study demonstrated that CD40L mediated interaction between T cells and stromal cells plays a vital role in the dysregulation of osteoblastogenesis and osteoclastogenesis in OVX-induced OP (125)